God's Kratom Kingdom hplc labs, facility & more.

 TERMS &  CONDITIONS

We have a third-party USA Licensed Pharmaceutical Testing Facility AL2A & 17025 certified complete H.P.L.C. testing on our kratom. We measure the exact levels of 7-OH & Mitragynine alkaloid. 7-OH is the primary analgesic alkaloid/molecule that determines kratom potency. This is a direct NIH.gov quote:

Wait... lol, first & foremost the source of this scientific data is NIH.gov & is quoted with a direct link & is not medical advice or anything like that. ALL our kratom is distributed as "memorabilia" so we comply with the FDA's kratom consumption ban as we continue to follow life saving NIH.gov information about kratom & 7OH & save American lives (68,000 American lives saved per year potentially) with this Godsend plant. Now back to the NIH.gov quote:

"Among these alkaloids, 7-hydroxymitragynine showed the most potent opioid effect on the electrically-stimulated contraction (pD (2) = 8.38 +/- 0.12). The potency, calculated using pD (2) values, was 30- and 17-fold higher than that of mitragynine and morphine, respectively. Antagonism of naloxone on concentration-response curves for 7-hydroxymitragynine confirmed its opioid effect. These results suggest that the opioid effect of M. speciosa is mostly based on the activity of 7-hydroxymitragynine."  https://pubmed.ncbi.nlm.nih.gov/15770543/

Additionally, mitragynine pseudoindoxyl developed analgesic tolerance more slowly than morphine, showed limited physical dependence, respiratory depression, constipation, and displayed no reward or aversion in CPP/CPA assays, suggesting that analogs might represent a promising new generation of novel pain relievers.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344672/

7-OH is the alkaloid that determines how strong kratom is.

Our kratom tested 20x HIGHER 7-OH THAN THE MARKET AVERAGE 

20x is a literal fact from NIH.gov data! Here is a direct quote from NIH.gov:

Kratom contains a number of indole alkaloids that are believed to be the primary contributors to its psychoactive effects. Chief among these is mitragynine (FigureFigure11), which typically constitutes 1–2% of the dry leaf mass and up to approximately two-thirds of the total alkaloid content.1,5 This compound is joined by 7-hydroxymitragynine (7-OH, FigureFigure11) in much lower concentrations, typically less than 0.05% of the dried leaf mass.1,20 The other predominant alkaloids found in kratom leaf are speciogynine, speciociliatine, and paynantheine (each ∼0.2–0.5% of dry leaf mass), but at this time little is known about their pharmacology.1,5 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598159/#ref5

So direct from NIH.gov we know the typical alkaloid level of 7-OH is 0.050% which is 20 times less than our HPLC labs at 1.000% In case you haven't seen them, attached is HPLC lab testing for our world record batch! We have an average of 4x potency & up to 20x potency documented in a pharmaceutical testing facility located in California. Customers can call Micro Quality Labs directly to verify the lab results.

KRATOM KINGDOM IS LITERALLY THE WORLD'S STRONGEST KRATOM! Tested in an ISO 17025 certified & AL2A accredited pharmaceutical grade laboratory. 

Here is an important Godsend bit of scientific data about 7-OH from NIH.gov about kratom potential to end the epidemic! Kratom saves by preventing the way too common lethal side effect of respiratory depression & other common side effects from painkillers:

"In a previous report, both mitragynine and 7-OH were found to display G protein-biased agonism at the mu-opioid receptor,8 a concept which gained significance in drug discovery over the recent years, where G protein-biased mu-opioid receptor agonists may deliver the desired analgesia without the unwanted side effects."

"Overall, this work provides knowledge that can be used for creating novel pain therapeutics based on kratom. The Mitragyna alkaloid scaffold represents an attractive framework for the development of functionally biased opioid modulators, which may exhibit improved therapeutic profiles as analgesic drugs. In particular, respiratory safety is of major importance to clinicians due to the risk for fatal outcomes and because respiratory suppression is the primary cause of opioid-related overdose mortality. The pharmacological profile of 7-OH as a partial G protein-biased agonist at the mu-opioid receptor would signify a desirable, wide analgesia-respiratory depression therapeutic window." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598155/ 

"The most significant advantage of kratom is that it has not caused any overdose deaths.""Data also suggest that kratom has the potential to prevent opioid overdoses, a rising killer in the U.S. population."https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601368/

Our Nation's NIH 7-OH data is all worth reading. There is WAY more info online! Google search 7-OH NIH.gov to access more USA lifesaving data!

We are always here to look out for you personally, if you ever have any Kratom needs that you need help with please let me know and I am always here to make sure you do not suffer. This plant has reduced so much suffering for me & nothing makes me as happy as helping another person not suffer & not end up part of the death statistics from an opioid or NSAIDs like ibuprofen.

DID YOU KNOW THAT IBUPROFEN & OVER-THE COUNTER NSAIDs KILL OVER 16,000 AMERICANS PER YEAR? GOOGLE SEARCH THIS: "How many Americans die from ibuprofen annually?" Americans have a life-threatening condition of suffering that is killing so many people but we can & will change this growing epidemic with this plant made by the creator of this earth. Please share the SAVE THY NEIGHBOR kratom awareness movement by sharing life saving information about kratom from NIH.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598155/

We are in this industry to serve our country and the American people and end a problem that is currently taking one innocent American citizen's life every 11 minutes; every 11 minutes another American is found dead! More needed and wanted American lives are taken from the opioid epidemic than were taken from all terrorist acts combined! Beyond any shadow of a doubt kratom is the only way I was able to free myself from ending up dead from an opioid! I'm so grateful that I have something that is able to help alleviate my pain from scoliosis and yet not take away my ability to work! That is the magic of Kratom, it takes away the pain for me without taking away my ability to perform well or my ability to focus strongly, or my ability to always treat others kindly. I would not be where I am in life with productivity & my ability to contribute to society without kratom.  

The future of our country in the future of each and every human as an individual and their family is all controlled and determined by the way that humans feel. It is so important that we start to make plants that control the way humans feel part of our daily conversation so that they can become part of every human life and every human will feel happy and be productive every day instead of the daily tragedies that the news is always full of literally everyday.

Let's make our lives in this part of American history the happiest and most productive of all time, we absolutely can and we absolutely will if we can control and change the way humans feel as individuals and Kratom gives me the ability to do that without fail!

Thank you for being part of my life, I'm here to make your life awesome, together we can make life on Earth anything we decide it's going to be and it can be everyone's definition of perfect. So let's get to it. I hope to hear from you soon and to serve you forever.

As Americans we have a huge advantage as USA Citizens by being able to access the United US National Library of Medicine & National Institutes of Health. With this source we get access to the information that can save 1 American life every 11 minutes!!! THIS IS A REALLY BIG DEAL, saving more Americans lives from early & preventable death than forever removing terrorism. More innocent lives are taken from opioids by accident than any act of terrorism. It is a terrifying fact & kratom has always been my lifesaving plant to keep me safe in my American pursuit of happiness. Please share the SAVE THY NEIGHBOR kratom awareness movement by sharing lifesaving information about kratom from NIH.gov https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6598155/

We are here to contribute to your life! Together we can contribute so much to our country & save 1 American life every 11 minutes. We are here to always guarantee the best product and be the best contribution towards your life and improving it in a sustainable way. We are here to create a product of perfection & evolve the Kratom industry with a product that will work wonders to help end our country's opioid epidemic that is currently taking over 100 AMERICAN LIVES PER DAY! Together we can change this tragic fact as we work to make life & the pursuit of happiness the safe path it was meant to be!

HAVE NO MONEY FOR KRATOM?

BROKE AS A JOKE THAT'S NOT FUNNY?

I HAVE BEEN THERE TOO. WE'LL STILL HELP YOU! 

TEXT US ABOUT YOUR SITUATION & WE'LL ALWAYS LOOK OUT FOR YOU!

Please let us know if you need anything. We are always here to serve you the best and make your life the best with the world's best Kratom. UNITED WE STAND - DIVIDED WE FALL

Passionately pursuing American health and happiness,

Sterling Carl Tucker

GOD'S KRATOM KINGDOM

www.KratomKingdom.online

IN GOD WE TRUST GOD'S PLANTS

The World's Strongest Lab-Verified Kratom

LET'S MAKE AMERICA SAFE & PRODUCTIVE WITH KRATOM

MORE LIVE SAVING INFORMATION ABOUT 7OH FROM NIH:

Direct quote from the USA National Library of Medicine & National Institutes of Health:

UNVEILING 7-HYDROXYMITRAGYNINE AS THE KEY ACTIVE METABOLITE

Debilitating pain is a constant backdrop of daily life, resulting in personal suffering, substantial health costs, and an economic burden for society. Pain is not only a disabling symptom of many medical conditions but also a disease state in its own right. With its prevalence in 20–30% of the adult population, chronic pain affects more people than heart disease, cancer, and diabetes combined and will continue to grow as our population ages.1 Pain medicine represents one of the most rapidly developing medical specialties of today, with effective pain control being a therapeutic priority. Chronic pain is still poorly managed because of the lack of efficacious therapies and significant adverse side effects of currently available analgesic drugs.2 Now, the article of Kruegel et al. presents different pain therapeutics based on a natural product, Mitragyna speciosa, and new insights into its pharmacology and analgesic activity.3

Opioids are highly effective analgesics and the most widely prescribed class of medications in the US.4 Most opioid analgesics (e.g., morphine, fentanyl, and oxycodone) used in clinical practice target mu-opioid receptors.2 Medical use and misuse of opioids have strongly increased in the past decades. It has emerged as a major public health threat due to the dramatic rise in opioid-related overdose deaths (over 47 000 in 2017 or 67.8% of all drug overdose deaths) and diagnoses of opioid-use disorder (addiction) associated with prescription opioids (1.8 million in 2016). The cost of the opioid epidemic in the US is estimated to be $80 billion annually.4,5

Medicinal plants are tremendous sources of new drug candidates. Lately, there has been a renewed interest in natural product research due to the failure of alternative drug discovery methods to deliver many lead compounds in key therapeutic areas such as pain. Mitragyna speciosa, known as “kratom”, a plant native to Southeast Asia, has been used traditionally as a stimulant and analgesic and for the treatment of opioid ddiction.6 During the past years, kratom use has become increasingly popular in the US, where the consumption of kratom leaves was reported as an efficacious treatment of pain, particularly in cases where other available treatments have either failed or caused intolerable side effects.7 A significant number of users have also reported use of kratom as a tool to stop or reduce the use of prescription or illicit opioids—a potential application that is nowadays gaining high attention given the ongoing opioid abuse epidemic in the US.

Given the unique and fascinating pharmacology surrounding mitragynine, the major alkaloid in kratom, Kruegel et al.3 present a systematic study on the metabolism-dependent mechanism for the analgesic effects of mitragynine. It offers a possible explanation for the apparently safer profile of mitragynine compared to classical opioids. In their report, the authors rationalized the importance of 7-hydroxymitragynine (7-OH) as an active metabolite of mitragynine and a key mediator of its analgesic activity, thus providing the essential in vivo link signifying the pharmacological relevance of 7-OH 

In a previous report, both mitragynine and 7-OH were found to display G protein-biased agonism at the mu-opioid receptor,8 a concept which gained significance in drug discovery over the recent years, where G protein-biased mu-opioid receptor agonists may deliver the desired analgesia without the unwanted side effects. In their latest work published in ACS Central Science,3 the authors have proven that, besides the conversion of mitragynine to 7-OH via chemical oxidation, mitragynine can also undergo biotransformation in vitro in both mouse and human liver preparations to 7-OH, with cytochrome P450 3A4 as the main metabolic pathway (Figure​Figure11). In both microsome preparations, 7-OH was the major metabolite and was produced concomitant with the disappearance of mitragynine. The metabolic conversion was more efficient in human liver microsomes suggesting that an appreciation of interspecies differences is likely to be important for understanding the pharmacology of mitragynine. Mitragynine as well as 7-OH were highly stable in mouse plasma, indicating that plasma metabolism does not contribute significantly to the biotransformation of these alkaloids. 7-OH was reported earlier as having much higher analgesic potency in mice after subcutaneous (s.c.) administration compared to mitragynine and morphine.6 Using genetic approaches, the authors demonstrated in vivo that mitragynine and 7-OH produce analgesic effects acting through a mu-opioid receptor-dependent mechanism.3 They have demonstrated that metabolic conversion of mitragynine to 7-OH occurred also in vivo, where both alkaloids were detected in the plasma and brain, confirming that 7-OH is formed as a metabolite of mitragynine and that it enters the brain. Further, the authors have proven in mice that 7-OH contributes to the analgesic activity of mitragynine as a metabolite when comparing the pain response of compounds given at equianalgesic s.c. doses and confirmed this by quantifying concentrations of 7-OH in the brain, thus being consistent with 7-OH as the primary mediator of central analgesic activity. At the same time, other groups independently described the formation of 7-OH as a metabolite of mitragynine in vitro and in vivo.9,10

However, pharmacokinetic studies will be required to elucidate the importance of 7-OH as a mitragynine metabolite in man, where the interspecies differences in the metabolic processes must be carefully considered. Overall, this work provides knowledge that can be used for creating novel pain therapeutics based on kratom. The Mitragyna alkaloid scaffold represents an attractive framework for the development of functionally biased opioid modulators, which may exhibit improved therapeutic profiles as analgesic drugs. In particular, respiratory safety is of major importance to clinicians due to the risk for fatal outcomes and because respiratory suppression is the primary cause of opioid-related overdose mortality. The pharmacological profile of 7-OH as a partial G protein-biased agonist at the mu-opioid receptor would signify a desirable, wide analgesia-respiratory depression therapeutic window. Many challenges still lie ahead in the process of solving the current opioid epidemic.

Will this plant save 47,000 American lives per year? It depends on your choice of conversation...

So is Kratom really a good way to avoid pain & a high risk of accidental death? According to the International Journal of Drug Policy quoting several renown doctors & pain specialists:

The most significant difference from opioids is that, even at very high doses, kratom is much less likely to depress respiration (to a fatal degree) than classical opioids (Singh, Narayanan et al., 2018, 2016; Varadi et al., 2016). Further, at the molecular level, mitragynine has a chemical structure that is quite different from classical opioids such as morphine, which are mostly derived from the alkaloids of the opium poppy (Adkins et al., 2011; Kruegel & Grundmann, 2018; Prozialeck et al., 2012; Takayama, 2004). Recent studies indicate that even though mitragynine acts on opioid receptors, its over-all molecular actions are quite different from those of classical opioids (Henningfield et al., 2018; Prozialeck et al., 2012). In two recent studies, Varadi et al. (2016) and Kruegel et al. (2016)demonstrated that mitragynine and several related compounds act as G protein-biased agonists at the mu-opioid receptor (MOR). In other words, although they activated G protein-mediated signaling pathways, much like classical opioids, they did not activate the β-arrestin-2 signaling pathway, which has been implicated as a mediator of some opioid-induced side effects, including respiratory depression(Raehal & Bohn, 2014; Schmid et al., 2017). Accordingly, the avoidance of β-arrestin-2 activation may in part explain the apparent respiratory safety of kratom, despite other opioid-like effects. These studies also showed mitragynine to be a partial agonist at MOR, as compared to most classical opioids, which are full agonists. Partial activity is also expected to attenuate the severity of side effects. For example, buprenorphine, a partial agonist at MOR, exhibits a dose ceiling for respiratory depression (Dahan et al., 2005).

Importantly, the improved side effect profile of mitragynine and related compounds has also been supported by preliminary animal studies. An early study with mitragynine demonstrated attenuated respiratory depression and constipation for this compound compared to the classical opioid morphine in several animal species (Macko, Weisbach, & Douglas, 1972). Further, the Varadi study (Varadi et al., 2016) demonstrated in mice that a mitragynine-derived compound, mitragynine pseudoindoxyl, induced marked analgesic effects, but with attenuated respiratory depression, slower development of tolerance, and lower rewarding effects than morphine. Accordingly, both the natural compounds in kratom (e.g. mitragynine) and synthetic derivatives thereof may represent a new class of opioid-acting drugs with an improved window between therapeutic effects and negative side effects.

As a result of its ability to interact with opioid receptors, mitragynine is often referred to as an “opioid”. On the other hand, a large volume of evidence indicates that mitragynine produces physiological, biochemical and behavioral effects that differ from those of classical opioids. Even though some effects of mitragynine may involve partial activation of MOR, mitragynine is able to interact with many other receptors that classical opioids do not bind (Boyer et al., 2008). In light of this evidence, mitragynine and its analogs can best be described as “atypical opioids” (Raffa, Pergolizzi, Taylor, Ossipov, & Group, 2018), and may actually represent a unique class of drugs.

As citizens of the United States of America, each and every one of us has the incredible life advantage of learning what actually works and what doesn't work based on medical data obtained from a non-bias group and our country's NIH hub is the perfect place to do the job. I believe as our founding fathers did, that each of us has a RIGHT to LIFE, LIBERTY, & the pursuit of HAPPINESS. It is called the "pursuit" of happiness because happiness is not something that we obtain & then have forever, but rather something that we feel while living in a way the contributes to each other which requires continual action. So let's pursue happiness by being caring humans that look out for each other & share lifesaving information directly from the USA National Institutes of Health.