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Kratom (Mitragyna speciosa) is a natural leaf, consumed safely for centuries. Its key alkaloids, mitragynine and 7-hydroxymitragynine (7-OH), are unique: unlike classical opioids, they are partial, G-protein–biased agonists at the μ-opioid receptor. This means they deliver analgesia without the respiratory depression that causes nearly all opioid overdose deaths.

Scientific Evidence of Safety

• PubMed ID 15770543: 7-OH is 17x more potent than morphine in lab assays but does not recruit the β-arrestin pathway that drives respiratory depression.
   
• PMC6598155: 7-OH demonstrates G-protein bias, widening the safety margin between pain relief and respiratory suppression.
   
• PMC5344672: Mitragynine pseudoindoxyl (a downstream metabolite) produced less dependence, slower tolerance, and no conditioned reward/aversion compared to morphine.
   
• PMC5601368: “The most significant advantage of kratom is that it has not caused any overdose deaths.” Data suggest kratom may prevent opioid overdoses.
   

Public Health Contrast
NSAIDs (ibuprofen, naproxen, etc.) kill an estimated 15,000–17,000 Americans each year through GI bleeding, ulcers, and kidney failure — often in elderly arthritis patients taking them as prescribed. By contrast, kratom has never caused death via respiratory depression.

Metabolic Consideration
Mitragynine converts to 7-OH in the liver, but also produces several less favorable metabolites. Consumers chasing relief through high mitragynine doses face greater risk. Higher natural 7-OH content is safer, because it delivers pain relief directly without excessive metabolic burden.

Conclusion
Kratom is a leaf — a food. To restrict Americans from consuming it while steering them toward ibuprofen and opioids, which kill tens of thousands annually, is scientifically indefensible and morally wrong. The evidence is clear: kratom saves lives.